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Artificial hippocampal system restores long-term memory, enhances cognitiion

June 17, 2011

Artificial hippocampal system restores long-term memory capability (credit: USC Viterbi School of Engineering)

Theodore Berger and his team at the USC Viterbi School of Engineering’s Department of Biomedical Engineering have developed a neural prosthesis for rats that is able to restore their ability to form long-term memories after they had been pharmacologically blocked.

In a dramatic demonstration, Berger blocked the ability to rats to form long-term memories by using pharmacological agents to disrupt the neural circuitry that communicates between two subregions of the hippocampus, CA1 and CA3, which interact to create long-term memory, prior research has shown.

The rats were unable to remember which lever to pull to gain a reward, or could only remember for 5–10 seconds, when previously they could remember for a long period of time.

The researchers then developed an artificial hippocampal system that could duplicate the pattern of interaction between CA3-CA1 interactions. Long-term memory capability returned to the pharmacologically blocked rats when the team activated the electronic device programmed to duplicate the memory-encoding function.

The researchers went on to show that if a prosthetic device and its associated electrodes were implanted in animals with a normal, functioning hippocampus, the device could actually strengthen the memory being generated internally in the brain and enhance the memory capability of normal rats.

“These integrated experimental modeling studies show for the first time that with sufficient information about the neural coding of memories, a neural prosthesis capable of real-time identification and manipulation of the encoding process can restore and even enhance cognitive mnemonic processes,” says the paper.

Next steps, according to Berger and Deadwyler, will be attempts to duplicate the rat results in primates (monkeys), with the aim of eventually creating prostheses that might help human victims of Alzheimer’s disease, stroke, or injury recover function.

Ref.: “A Cortical Neural Prosthesis for Restoring and Enhancing Memory.” (Berger et al 2011 J. Neural Eng. 8 046017)

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